Psoriasis is one of the commonest inflammatory skin diseases determining a very high impact on patients' quality of life and daily activities and relationships. Several biologic therapies have been approved through the years for the treatment of moderate-to-severe plaque psoriasis, and efficacy and safety profile have been analyzed in clinical trials. Ixekizumab is an immunoglobulin G subclass 4 monoclonal antibody that selectively targets and binds IL-17A with high specificity and affinity. Inhibiting IL-17A activity, ixekizumab reduces and turns down levels of inflammation, resulting in the clinical improvement of the disease. Long-term efficacy and safety profile of ixekizumab have been investigated and reported in the UNCOVER trials, but in literature there are only few studies based on real life experience. We present the efficacy and safety profile of ixekizumab in a cohort of 779 patients affected by moderate-to-severe plaque psoriasis and treated with ixekizumab in 11 Italian dermatology hospitals, with a follow-up of care until 192 weeks.

Real life long-term efficacy and safety of ixekizumab in moderate-to-severe psoriasis: A 192 weeks multicentric retrospective study—IL PSO (Italian landscape psoriasis) / P. Malagoli, P. Dapavo, G. Pavia, F. Amoruso, G. Argenziano, F. Bardazzi, M. Burlando, C.G. Carrera, G. Damiani, V. Dini, G. Girolomoni, C. Guarneri, F. Loconsole, A. Narcisi, F. Sampogna, M. Travaglini, A. Costanzo. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - 35:8(2022 Aug), pp. e15608.1-e15608.5. [10.1111/dth.15608]

Real life long-term efficacy and safety of ixekizumab in moderate-to-severe psoriasis: A 192 weeks multicentric retrospective study—IL PSO (Italian landscape psoriasis)

G. Damiani;
2022

Abstract

Psoriasis is one of the commonest inflammatory skin diseases determining a very high impact on patients' quality of life and daily activities and relationships. Several biologic therapies have been approved through the years for the treatment of moderate-to-severe plaque psoriasis, and efficacy and safety profile have been analyzed in clinical trials. Ixekizumab is an immunoglobulin G subclass 4 monoclonal antibody that selectively targets and binds IL-17A with high specificity and affinity. Inhibiting IL-17A activity, ixekizumab reduces and turns down levels of inflammation, resulting in the clinical improvement of the disease. Long-term efficacy and safety profile of ixekizumab have been investigated and reported in the UNCOVER trials, but in literature there are only few studies based on real life experience. We present the efficacy and safety profile of ixekizumab in a cohort of 779 patients affected by moderate-to-severe plaque psoriasis and treated with ixekizumab in 11 Italian dermatology hospitals, with a follow-up of care until 192 weeks.
ixekizumab; long-term efficacy; real-life experience;humans; interleukin-17; quality of life; retrospective studies; severity of illness index; treatment outcome; antibodies, monoclonal, humanized; dermatologic agents; psoriasis
Settore MED/35 - Malattie Cutanee e Veneree
ago-2022
Article (author)
File in questo prodotto:
File Dimensione Formato  
Dermatologic Therapy - 2022 - Malagoli - Real life long‐term efficacy and safety of ixekizumab in moderate‐to‐severe.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 820.87 kB
Formato Adobe PDF
820.87 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1021881
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 10
social impact