Autologous Fat Graft with Mechanical Activation for Chronic Ulcers – A Case Report

In recent years, Autologous Fat Grafting (AFG) and related therapies using Adipose-derived stem cells (ADSCs) have garnered increasing attention for their potential in regenerating tissue. However, the available literature exhibits substantial variation, making it difficult to determine whether AFG is superior to conventional wound care or other treatments. Based on our research findings and other evidence presented in the literature, it appears that adult mesenchymal stem cells from the stromal fraction of harvested fat play an active role in certain processes. Autologous fat, when activated by mechanical method, seems to have even more promising results. We present the clinical case of a 78year-old male who suffered from right leg chronic osteomyelitis resulting in sporadic episodes of recrudescence and a chronic ulcer. As Autologous Fat Grafting (AFG) becomes increasingly recognized as a viable treatment option for cutaneous wounds, we have incorporated a novel approach to the Coleman technique by utilizing an orbital mechanical force of 97 G on adipose tissue for 6-10 minutes to activate the fat. The patient underwent weekly medications with a progressive improvement of his clinical picture. The treatment of ulcers by fat grafting activated is yielding encouraging results and, in our opinion, could become suitable in all types of ulcers as an additional or alternative procedure with low morbidity.