Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.
Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor / F. Reno’, M. Rizzi, M. Invernizzi, M. Migliario, C. Cisari. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 721:1-3(2013 Dec), pp. 301-304. [10.1016/j.ejphar.2013.08.044]
Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor
F. Reno’
Primo
;
2013
Abstract
Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.
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