Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. A large body of literature has been published describing various assays for the measurement of chemokines in biologic fluids and tissues. We review information available on the role of chemokines in selected human diseases and provide examples of clinical situations in which chemokine determination might be of practical value, and we describe the currently available assays for their measurement.

Chemokines and their receptors : roles in specific clinical conditions and measurement in the clinical laboratory / M. Locati, R. Bonecchi, M.M. Corsi. - In: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0002-9173. - 123:Suppl.(2005), pp. 82-95. [10.1309/M6U4B8L6TNAK4G9L]

Chemokines and their receptors : roles in specific clinical conditions and measurement in the clinical laboratory

M. Locati
Primo
;
R. Bonecchi
Secondo
;
M.M. Corsi
Ultimo
2005

Abstract

Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. A large body of literature has been published describing various assays for the measurement of chemokines in biologic fluids and tissues. We review information available on the role of chemokines in selected human diseases and provide examples of clinical situations in which chemokine determination might be of practical value, and we describe the currently available assays for their measurement.
Chemokines, inflammation, diagnostic markers
Settore MED/04 - Patologia Generale
Settore MED/05 - Patologia Clinica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/10202
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 36
  • ???jsp.display-item.citation.isi??? ND
social impact