A very attractive approach toward 1,3-polyheterocyclic systems was provided exploiting the copper-catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five-, six-, and seven-membered polyheterocyclic rings.

Methanol as a C1 Source for the Synthesis of 1,3-Polyheterocyclic Systems / L. Molteni, E.M. Beccalli, L. Castoldi, G. Broggini, C. Loro. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - 26:48(2023 Dec 19), pp. e202301106.1-e202301106.8. [10.1002/ejoc.202301106]

Methanol as a C1 Source for the Synthesis of 1,3-Polyheterocyclic Systems

L. Molteni
Primo
;
E.M. Beccalli
Secondo
;
L. Castoldi;
2023

Abstract

A very attractive approach toward 1,3-polyheterocyclic systems was provided exploiting the copper-catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five-, six-, and seven-membered polyheterocyclic rings.
1,3-polyheterocycles; copper-catalysis; hydrogen peroxide; methanol; oxidative conditions;
Settore CHIM/06 - Chimica Organica
19-dic-2023
13-nov-2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1019811
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