A very attractive approach toward 1,3-polyheterocyclic systems was provided exploiting the copper-catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five-, six-, and seven-membered polyheterocyclic rings.
Methanol as a C1 Source for the Synthesis of 1,3-Polyheterocyclic Systems / L. Molteni, E.M. Beccalli, L. Castoldi, G. Broggini, C. Loro. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - (2023), pp. e202301106.1-e202301106.8. [Epub ahead of print] [10.1002/ejoc.202301106]
Methanol as a C1 Source for the Synthesis of 1,3-Polyheterocyclic Systems
L. MolteniPrimo
;E.M. Beccalli
Secondo
;L. Castoldi;
2023
Abstract
A very attractive approach toward 1,3-polyheterocyclic systems was provided exploiting the copper-catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five-, six-, and seven-membered polyheterocyclic rings.
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