Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients' samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.

Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers? / L.F. Pisani, I. Teani, M. Vecchi, L. Pastorelli. - In: CELLS. - ISSN 2073-4409. - 12:11(2023 May 26), pp. 1481.1-1481.15. [10.3390/cells12111481]

Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?

M. Vecchi
Penultimo
;
L. Pastorelli
Ultimo
2023

Abstract

Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients' samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.
colorectal cancer; esophageal cancer; gastric cancer; inflammation; interleukin-33
Settore MED/12 - Gastroenterologia
26-mag-2023
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1019599
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