Since the beginning of the pandemic, SARS-CoV-2 has shown genetic variability. All the variants that have sustained pandemic waves have shown several mutations, especially in the Spike protein that could affect viral pathogenesis. A total of 15,729 respiratory samples, collected between December 2020 and August 2022, have been included in this study. We report the circulation of SARS-CoV-2 variants in the Lombardy region, Italy, in a 2-year study period. Alpha, Delta, and Omicron variants became predominant causing the majority of cases whereas Beta or Gamma variants mostly caused local outbreaks. Next-generation sequenc-ing revealed several mutations and few deletions in all of the main variants. For example, 147 mutations were observed in the Spike protein of Omicron sublineages; 20% of these mutations occurred in the recep-tor-binding domain region.
An overview of SARS-CoV-2 variants circulating in the 2020–2022 period in Lombardy / F. Giardina, G. Ferrari, F. Zavaglio, S. Paolucci, F. Rovida, G. Campanini, L. Pellegrinelli, C. Galli, E. Pariani, F. Bergami, A. Nava, E. Matarazzo, S. Renica, D. Fanti, V. Cento, C. Alteri, F. Scaglione, C. Vismara, C.F. Perno, A. Piralla, F. Baldanti. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 107:4(2023 Dec), pp. 116070.1-116070.5. [10.1016/j.diagmicrobio.2023.116070]
An overview of SARS-CoV-2 variants circulating in the 2020–2022 period in Lombardy
L. Pellegrinelli;C. Galli;E. Pariani;S. Renica;C. Alteri;F. Scaglione;
2023
Abstract
Since the beginning of the pandemic, SARS-CoV-2 has shown genetic variability. All the variants that have sustained pandemic waves have shown several mutations, especially in the Spike protein that could affect viral pathogenesis. A total of 15,729 respiratory samples, collected between December 2020 and August 2022, have been included in this study. We report the circulation of SARS-CoV-2 variants in the Lombardy region, Italy, in a 2-year study period. Alpha, Delta, and Omicron variants became predominant causing the majority of cases whereas Beta or Gamma variants mostly caused local outbreaks. Next-generation sequenc-ing revealed several mutations and few deletions in all of the main variants. For example, 147 mutations were observed in the Spike protein of Omicron sublineages; 20% of these mutations occurred in the recep-tor-binding domain region.File | Dimensione | Formato | |
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