This research compared the capability of urinary trans,trans-muconic acid (t,t-MA), S-phenylmercapturic acid (S-PMA) and benzene excreted in urine (U-benzene) to monitor low benzene exposure and evaluated the influence of smoking habit on these indices. Gasoline attendants, urban policemen, bus drivers and two groups of referents working in two large Italian cities (415 people) were studied. Median benzene exposure was 61, 22, 21, 9 and 6 microg/m3, respectively, with higher levels in workers than in referents. U-benzene, but not t,t-MA and S-PMA, showed an exposure-related increase. All the biomarkers were strongly influenced by cigarette smoking, with values up to five-fold higher in smokers compared to non-smokers. In conclusion, in the range of investigated benzene exposure (<478 microg/m3 or <0.15 ppm), the smoking habit may be regarded as a major source of benzene intake; among the study indices, U-benzene is the marker of choice for the biological monitoring of occupational and environmental exposure.
Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure / S. Fustinoni, M. Buratti, L. Campo, A. Colombi, D. Consonni, A.C. Pesatori, M. Bonzini, P. Farmer, S. Garte, F. Valerio, D.F. Merlo, P.A. Bertazzi. - In: CHEMICO-BIOLOGICAL INTERACTIONS. - ISSN 0009-2797. - 153-154(2005), pp. 253-256.
|Titolo:||Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure|
FUSTINONI, SILVIA (Primo)
BERTAZZI, PIETRO ALBERTO (Ultimo)
|Parole Chiave:||Benzene; Biomarkers; Occupational exposure; S-Phenylmercapturic acid; trans,trans-Muconic acid; Urinary excretion|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.cbi.2005.03.031|
|Appare nelle tipologie:||01 - Articolo su periodico|