Exposures to fine particulate matter (PM1 ) have been associated with health impacts, but the understanding of the PM1 concentration-response (PM1-CR) relationships, especially at low PM1 , remains incomplete. Here, we present novel data using a methodology to mimic lung exposure to ambient air (2< PM1 < 60 μg m−3), with minimized sampling artifacts for nanoparticles. A reference model (Air Liquid Interface cultures of human bronchial epithelial cells, BEAS-2B) was used for aerosol exposure. Non-linearities observed in PM1-CR curves are interpreted as a result of the interplay between the aerosol total oxidative potential (OPt ) and its distribution across particle size (dp ). A d p-dependent condensation sink (CS) is assessed together with the distribution with d p of reactive species . Urban ambient aerosol high in OPt , as indicated by the DTT assay, with (possibly copper-containing) nanoparticles, shows higher pro-inflammatory and oxidative responses, this occurring at lower PM1 concentrations (< 5 μg m−3). Among the implications of this work, there are recommendations for global efforts to go toward the refinement of actual air quality standards with metrics considering the distribution of OPt with d p also at relatively low PM1.

Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation / F. Costabile, M. Gualtieri, M. Rinaldi, S. Canepari, R. Vecchi, L. Massimi, G. Di Iulio, M. Paglione, L. Di Liberto, E. Corsini, M.C. Facchini, S. Decesari. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), pp. 18616.1-18616.18. [10.1038/s41598-023-45230-z]

Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation

R. Vecchi;E. Corsini;
2023

Abstract

Exposures to fine particulate matter (PM1 ) have been associated with health impacts, but the understanding of the PM1 concentration-response (PM1-CR) relationships, especially at low PM1 , remains incomplete. Here, we present novel data using a methodology to mimic lung exposure to ambient air (2< PM1 < 60 μg m−3), with minimized sampling artifacts for nanoparticles. A reference model (Air Liquid Interface cultures of human bronchial epithelial cells, BEAS-2B) was used for aerosol exposure. Non-linearities observed in PM1-CR curves are interpreted as a result of the interplay between the aerosol total oxidative potential (OPt ) and its distribution across particle size (dp ). A d p-dependent condensation sink (CS) is assessed together with the distribution with d p of reactive species . Urban ambient aerosol high in OPt , as indicated by the DTT assay, with (possibly copper-containing) nanoparticles, shows higher pro-inflammatory and oxidative responses, this occurring at lower PM1 concentrations (< 5 μg m−3). Among the implications of this work, there are recommendations for global efforts to go toward the refinement of actual air quality standards with metrics considering the distribution of OPt with d p also at relatively low PM1.
No
English
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore BIO/14 - Farmacologia
Articolo
Esperti anonimi
Pubblicazione scientifica
   Redox-activity and Health-effects of Atmospheric Primary and Secondary aerosol (RHAPS)
   RHAPS
   MINISTERO DELL'ISTRUZIONE E DEL MERITO
   2017MSN7M8_002
2023
Nature Publishing Group
13
1
18616
1
18
18
Pubblicato
Periodico con rilevanza internazionale
crossref
Aderisco
info:eu-repo/semantics/article
Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation / F. Costabile, M. Gualtieri, M. Rinaldi, S. Canepari, R. Vecchi, L. Massimi, G. Di Iulio, M. Paglione, L. Di Liberto, E. Corsini, M.C. Facchini, S. Decesari. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), pp. 18616.1-18616.18. [10.1038/s41598-023-45230-z]
open
Prodotti della ricerca::01 - Articolo su periodico
12
262
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Periodico con Impact Factor
F. Costabile, M. Gualtieri, M. Rinaldi, S. Canepari, R. Vecchi, L. Massimi, G. Di Iulio, M. Paglione, L. Di Liberto, E. Corsini, M.C. Facchini, S. Decesari
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1013948
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