Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity of coronary microvascular dysfunction (CMD) in CADASIL patients.

Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy / A. Argirò, R. Sciagrà, A. Marchi, M. Beltrami, E. Spinelli, E. Salvadori, A. Bianchi, M. Mascalchi, A. Poggesi, I. Olivotto, F. Pescini. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - 28:11(2021 Nov), pp. 3809-3813. [10.1111/ene.14678]

Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

E. Salvadori;
2021

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity of coronary microvascular dysfunction (CMD) in CADASIL patients.
CADASIL; coronary microvascular dysfunction; positron emission tomography
Settore MED/26 - Neurologia
nov-2021
12-dic-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1008648
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