The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.

Recent advances of drugs monitoring in oral fluid and comparison with blood / S. Casati, M. Binda, P. Dongiovanni, M. Meroni, A. D'Amato, G. Roda, M. Orioli, M. DEL FABBRO, G.M. Tartaglia. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 61:11(2023), pp. 1978-1993. [10.1515/cclm-2023-0343]

Recent advances of drugs monitoring in oral fluid and comparison with blood

S. Casati
Primo
;
M. Binda
Secondo
;
P. Dongiovanni
;
M. Meroni;A. D'Amato;G. Roda;M. Orioli;M. DEL FABBRO
Penultimo
;
G.M. Tartaglia
Ultimo
2023

Abstract

The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.
alternative matrix; blood; drugs of abuse; drugs testing; saliva
Settore CHIM/08 - Chimica Farmaceutica
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore CHIM/01 - Chimica Analitica
2023
Article (author)
File in questo prodotto:
File Dimensione Formato  
10.1515_cclm-2023-0343 (1).pdf

Open Access dal 13/06/2024

Descrizione: Review
Tipologia: Publisher's version/PDF
Dimensione 926.95 kB
Formato Adobe PDF
926.95 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1008150
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact