Exercise intolerance represents a typical feature of heart failure with preserved ejection fraction (HFpEF), and is associated with a poor quality of life, frequent hospitalizations, and increased all-cause mortality. The cardiopulmonary exercise test is the best method to quantify exercise intolerance, and allows detection of the main mechanism responsible for the exercise limitation, influencing treatment and prognosis. Exercise training programs improve exercise tolerance in HFpEF. However, studies are needed to identify appropriate type and duration. This article discusses the pathophysiology of exercise limitation in HFpEF, describes methods of determining exercise tolerance class, and evaluates prognostic implications and potential therapeutic strategies.

Exercise Intolerance in Heart Failure with Preserved Ejection Fraction / A. Salzano, M. De Luca, M.Z. Israr, G. Crisci, M. Eltayeb, R. Debiec, B. Ranieri, R. D'Assante, S. Rega, A. D'Agostino, C. Mauro, I.B. Squire, T. Suzuki, E. Bossone, M. Guazzi, A.M. Marra. - In: HEART FAILURE CLINICS. - ISSN 1551-7136. - 17:3(2021 Jul), pp. 397-413. [10.1016/j.hfc.2021.03.004]

Exercise Intolerance in Heart Failure with Preserved Ejection Fraction

M. Guazzi
Penultimo
;
2021

Abstract

Exercise intolerance represents a typical feature of heart failure with preserved ejection fraction (HFpEF), and is associated with a poor quality of life, frequent hospitalizations, and increased all-cause mortality. The cardiopulmonary exercise test is the best method to quantify exercise intolerance, and allows detection of the main mechanism responsible for the exercise limitation, influencing treatment and prognosis. Exercise training programs improve exercise tolerance in HFpEF. However, studies are needed to identify appropriate type and duration. This article discusses the pathophysiology of exercise limitation in HFpEF, describes methods of determining exercise tolerance class, and evaluates prognostic implications and potential therapeutic strategies.
Aerobic capacity; Cardiac function; Exercise tolerance; Exercise training; Heart failure with preserved ejection fraction; Skeletal muscle function
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
lug-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1005828
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