Complex regional pain syndrome type I (CRPS I) is a multifactorial painful disorder with a complex pathogenesis. Both peripheral and central mechanisms are involved. Acute CRPS I is considered to be an exaggerated inflammatory disorder; however, over time, because of altered function of the sympathetic nervous system and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder. This review thoroughly describes the pathophysiological aspects of CRPS I and summarizes the potential therapeutic options. The mechanisms and targets of the treatment are different in the early and late stages of the disease. This current review builds on a previous review by this author group by deepening the role of the peripheral classic and neuronal inflammatory component in the acute stage of this painful disorder. Level of evidence: Not applicable.

Adult complex regional pain syndrome type I: A narrative review / M. Bussa, A. Mascaro, L. Cuffaro, S. Rinaldi. - In: PM & R. - ISSN 1934-1482. - 9:7(2017 Jul), pp. 707-719. [10.1016/j.pmrj.2016.11.006]

Adult complex regional pain syndrome type I: A narrative review

M. Bussa
Primo
;
2017

Abstract

Complex regional pain syndrome type I (CRPS I) is a multifactorial painful disorder with a complex pathogenesis. Both peripheral and central mechanisms are involved. Acute CRPS I is considered to be an exaggerated inflammatory disorder; however, over time, because of altered function of the sympathetic nervous system and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder. This review thoroughly describes the pathophysiological aspects of CRPS I and summarizes the potential therapeutic options. The mechanisms and targets of the treatment are different in the early and late stages of the disease. This current review builds on a previous review by this author group by deepening the role of the peripheral classic and neuronal inflammatory component in the acute stage of this painful disorder. Level of evidence: Not applicable.
CRPS; neuropathic pain; algodystrophy; epidemiology; pathophysiological mechanisms; maladaptive neuroplasticity; classic and neurogenic inflammation; diagnostic criteria; chronic pain
Settore MED/01 - Statistica Medica
Settore MED/09 - Medicina Interna
Settore MED/16 - Reumatologia
Settore MED/26 - Neurologia
Settore MED/34 - Medicina Fisica e Riabilitativa
Settore MED/41 - Anestesiologia
lug-2017
23-nov-2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1004808
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