Abstract: The antimicrobial properties of one of the most important secondary metabolites, Eugenol(EU), inspired us to design and synthesize three different series of derivatives enhancing its parent compound’s anti-Helicobacter pylori activity. Thus, we prepared semisynthetic derivatives through (A) diazo aryl functionalization, (B) derivatization of the hydroxy group of EU, and (C) elongation of the allyl radical by incorporating a chalcogen atom. The antibacterial evaluation was performed on the reference NCTC 11637 strain and on three drug-resistant clinical isolates and the minimal inhibitory and bactericidal concentrations (MICs and MBCs) highlight the role of chalcogens in enhancing the antimicrobial activity (less than 4 microg/mL for some compounds) of the EU scaffold (32–64 microg/mL).
Nature-Inspired Compounds: Synthesis and Antibacterial Susceptibility Testing of Eugenol Derivatives against H. pylori Strains / S. Carradori, A. Ammazzalorso, S. Niccolai, D. Tanini, I. D’Agostino, F. Melfi, A. Capperucci, R. Grande, F. Sisto. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 16:9(2023), pp. 1317.1-1317.19. [10.3390/ph16091317]
Nature-Inspired Compounds: Synthesis and Antibacterial Susceptibility Testing of Eugenol Derivatives against H. pylori Strains
F. SistoUltimo
2023
Abstract
Abstract: The antimicrobial properties of one of the most important secondary metabolites, Eugenol(EU), inspired us to design and synthesize three different series of derivatives enhancing its parent compound’s anti-Helicobacter pylori activity. Thus, we prepared semisynthetic derivatives through (A) diazo aryl functionalization, (B) derivatization of the hydroxy group of EU, and (C) elongation of the allyl radical by incorporating a chalcogen atom. The antibacterial evaluation was performed on the reference NCTC 11637 strain and on three drug-resistant clinical isolates and the minimal inhibitory and bactericidal concentrations (MICs and MBCs) highlight the role of chalcogens in enhancing the antimicrobial activity (less than 4 microg/mL for some compounds) of the EU scaffold (32–64 microg/mL).File | Dimensione | Formato | |
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