Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging / F. Brero, P. Calzolari, M. Albino, A. Antoccia, P. Arosio, M. Avolio, F. Berardinelli, D. Bettega, M. Ciocca, A. Facoetti, S. Gallo, F. Groppi, C. Innocenti, A. Laurenzana, C. Lenardi, S. Locarno, S. Manenti, R. Marchesini, M. Mariani, F. Orsini, E. Pignoli, C. Sangregorio, F. Scavone, I. Veronese, A. Lascialfari. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - 46:4(2023), pp. 126.1-126.4. (Intervento presentato al convegno SIF Congress tenutosi a Milano nel 2022) [10.1393/ncc/i2023-23126-6].
Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging
P. Calzolari;P. Arosio;D. Bettega;S. Gallo
;F. Groppi;C. Lenardi;S. Locarno;S. Manenti;F. Orsini;I. VeronesePenultimo
;A. LascialfariUltimo
2023
Abstract
Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d = 19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMR results showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H = 1.5 tesla, was ∼3 times higher than the one of commercial MRI contrast agents. The system displayed a SAR ∼ 110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
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