| Nome |
# |
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The regulation of the small heat shock protein B8 in misfolding protein diseases causing motoneuronal and muscle cell death, file dfa8b99f-2f92-748b-e053-3a05fe0a3a96
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184
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Insights into the neurodegenerative mechanisms associated with KIF5A mutations, file 56680d93-303f-47df-b795-36bf6c8530d4
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161
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How PQC inhibition modulates miRNA loading in large and small extracellular vesicles, file 21b0955f-899c-471d-9dd4-58f91281cc38
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140
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Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy, file dfa8b99f-4adc-748b-e053-3a05fe0a3a96
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131
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Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives, file dfa8b9a1-f092-748b-e053-3a05fe0a3a96
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107
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Multiple Roles of Transforming Growth Factor Beta in Amyotrophic Lateral Sclerosis, file dfa8b9a2-301d-748b-e053-3a05fe0a3a96
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105
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A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases, file dfa8b9a3-0fed-748b-e053-3a05fe0a3a96
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102
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Pathogenic variants of Valosin Containing Protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells, file e9d18bb1-67a8-43d4-aa12-75d15b29ae6f
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97
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Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7, file dfa8b9a6-e4c0-748b-e053-3a05fe0a3a96
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96
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Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins, file dfa8b9a9-da13-748b-e053-3a05fe0a3a96
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95
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TDP-43 PROTEINOPATHIES: THE ROLE OF EXTRACELLULAR VESICLES, file 27dc34a9-3d27-48c5-a369-e2d3c832a3ec
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90
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Insights into KIF5A-related pathways to neurodegeneration, file 138261e4-6e69-4f83-a528-4b5dd6c3c8d9
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72
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One gene, many phenotypes: investigating KIF5A-linked neurodegeneration mechanisms, file 86e3e1a7-695b-431f-8637-378366a4b8c6
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65
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Insights on human small heat shock proteins and their alterations in diseases, file dfa8b9a9-ad26-748b-e053-3a05fe0a3a96
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62
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Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy, file dfa8b9a9-a227-748b-e053-3a05fe0a3a96
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47
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Large and small extracellular vesicles may contribute to the propagation of ALS and FTD carrying toxic TDP species and potentially harmful miRNAs, file 35c1fa66-e63a-4b28-9e47-290afca853c5
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43
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The role of autophagy-lysosomal pathway in motor neuron diseases, file bbf9e809-278b-41af-9e60-753362497db9
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43
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HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies, file 4643b012-2d73-4531-9774-06eb91ee2634
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42
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Bicalutamide and Trehalose Ameliorate Spinal and Bulbar Muscular Atrophy Pathology in Mice, file d3a6c3cf-972a-4e04-b1d2-a62aba6a58be
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39
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Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases, file be05b08b-f354-4c6b-8379-4823c368429d
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31
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The role of extracellular vesicles in the removal of aggregated TDP43 responsible for ALS/FTD diseases, file dfa8b9a0-31b9-748b-e053-3a05fe0a3a96
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31
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Analysis of the pathogenetic mechanisms involved in KIF5A-related neurodegenerative disorders, file dfa8b9a9-f163-748b-e053-3a05fe0a3a96
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31
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RAN translated C9ORF72 arginine rich poly-dipeptides alter gene transcription in ALS/FTD cell model, file dfa8b9a0-202c-748b-e053-3a05fe0a3a96
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29
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The role of extracellular vesicles in TDP-43 proteinopathies, file 8550b912-bba9-4b20-a47c-685326e8edf0
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28
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Shared behaviours of KIF5A frameshift mutants in neurodevelopment and neurodegeneration, file d000fe03-ec7f-423f-9234-72bc7c9c72a9
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27
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VCP mutants cause lysosomal alterations and autophagy induction in ALS-neuronal model, file dfa8b9a7-aec2-748b-e053-3a05fe0a3a96
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22
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The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases, file bf74631b-d95e-48ae-995b-2f70e5976179
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21
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Mutations in VCP induce lysosomal alterations and autophagy activation in ALS neuronal models, file dfa8b9a7-6e91-748b-e053-3a05fe0a3a96
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18
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Alternative Translation Initiation as a novel strategy to block toxicity of the mutant Androgen Receptor in SBMA, file 48b97ee8-b599-40f0-b48c-82852033f279
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17
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Motor neuron degeneration in spinal and bulbar muscular atrophy: molecular approaches to counteract mutant androgen receptor neurotoxicity, file dfa8b9a0-408e-748b-e053-3a05fe0a3a96
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17
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The nucleotide exchange factor BAG1 prevents neurotoxic misfolded proteins accumulation via proteasome and chaperone mediated autophagy, file dfa8b9a1-1186-748b-e053-3a05fe0a3a96
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15
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Pathogenic variants of Valosin Containing Protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells, file dfa8b9aa-7aa2-748b-e053-3a05fe0a3a96
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15
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VCP ALS-mutants induce lysosomal damage and autophagy activation, file dfa8b9a7-83a9-748b-e053-3a05fe0a3a96
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14
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Molecular mechanisms in KIF5A-related neurodegeneration, file 7775af56-ab02-4fc8-bf74-70a686f327a1
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13
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Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases, file 84cb0293-2bbd-4a94-87ee-72cae0cd2891
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13
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Mutant Androgen Receptor Alternative Translation Initiation as novel strategy to block toxicity in SBMA., file b5bf0d92-d46c-45e2-835c-c5c2f3d5714d
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13
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VCP mutants induce lysosomal damage and autophagy activation in amyotrophic lateral sclerosis (ALS), file dfa8b9a7-5ef1-748b-e053-3a05fe0a3a96
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12
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STIP1 Homology And U-Box Containing Protein 1 (STUB1/CHIP) mutants as a key factor on TATA-box binding protein (TBP) behaviour in digenic spinocerebellar ataxia type 17 (SCA17-DI), file 702326c4-bfdc-4892-8e36-8b017f3939a2
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11
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Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7, file dfa8b9a7-0b72-748b-e053-3a05fe0a3a96
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11
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VCP modulation rescues C9ORF72 pathological features in ALS-neuronal models, file 58aaebf7-6e67-4471-837c-5eff5ce38e90
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9
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Innovative high throughput screening identifies HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases, file 69472320-619b-4c69-a538-f9b027c996f1
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9
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Proteotoxic responses in amyotrophic lateral sclerosis, file 845e09a9-63be-49cb-931e-3b6d8d8d06e9
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9
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Investigating the molecular mechanisms involved in KIF5A-related neurodegeneration, file 8f77a162-ac58-4c34-b798-bf74c414c4ec
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8
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Molecules capable to induce neuroprotection via lysophagy activation, file dfa8b9a1-2e6d-748b-e053-3a05fe0a3a96
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8
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Differentiation of isogenic iPSC reporter lines to motoneurons as tools for familial and sporadic amyotrophic lateral sclerosis, file dfa8b9a4-1b2c-748b-e053-3a05fe0a3a96
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7
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Analysis of the autophagic response in models of KIF5A-related neurodegeneration, file dfa8b9a7-024d-748b-e053-3a05fe0a3a96
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7
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C9ORF72 arginine rich poly-dipeptides induce transcriptional alterations in ALS/FTD cell model, file dfa8b99f-7778-748b-e053-3a05fe0a3a96
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4
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The BAG1 molecular chaperone regulators prevent ALS related neurotoxic misfolded proteins accumulation via proteasome and chaperone mediated autophagy, file dfa8b9a4-eb50-748b-e053-3a05fe0a3a96
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4
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Mechanism of paroxetine-mediated autophagic induction in cell models of ALS/FTD, file 680b2e1a-fd35-472a-a8e0-6f6d4a0a8f06
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3
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Frameshift mutations in the heat shock protein B8 cause its aggregation and impair proteostasis in neuromyopathies, file bf7c250c-b54a-480d-9c71-733e1609a9b9
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3
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THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS, file c55ae6bd-fbc9-4c2d-b260-d80d2c25163c
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3
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BAG1 assists the degradation of neurotoxic proteins related to motor neuron diseases counteracting dynein-mediated autophagy alteration, file dfa8b9a7-27ae-748b-e053-3a05fe0a3a96
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3
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Alternative translation initiatin as a novel strategy to block toxicity of the mutant androgen receptor in SBMA, file dfa8b9a0-275b-748b-e053-3a05fe0a3a96
|
2
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Frameshift mutations in the Heat Shock Protein B8 share common pathogenic mechanisms and impair proteostasis, file f3c0884b-c93f-4d06-b5de-e54fafc66317
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2
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Shared behaviours of KIF5A frameshift mutants in neurodevelopment and neurodegeneration, file 3b23df28-ff35-481b-b2e0-82de1f7ee43f
|
1
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Transcriptional alterations induced by polyDPRs overexpression in neuronal cell model, file dfa8b99e-8b98-748b-e053-3a05fe0a3a96
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1
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| Totale |
2.193 |