Sfoglia per Autore
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor
2016 A. Bock, M. Bermudez, F. Krebs, C. Matera, B. Chirinda, D. Sydow, C.M.L. Dallanoce, U. Holzgrabe, M. DE AMICI, M.J. Lohse, G. Wolber, K. Mohr
Dynamic ligand binding of dualsteric (allosteric/orthosteric) molecular probes controls the graded activation of muscarinic acetylcholine receptors
2016 C. Dallanoce, C. Matera, F. Krebs, A. Bock, M. Bermudez, R. Messerer, B. Chirinda, D. Sydow, M.J. Lohse, G. Wolber, M. De Amici, U. Holzgrabe, K. Mohr
Novel quinuclidine derivatives to investigate the alpha-7 nicotinic acetylcholine receptor activation: new insight and perspectives
2016 M. Quadri, C. Matera, A. Silnovic, M.C. Pismataro, N.A. Horenstein, R.L. Papke, C. Dallanoce
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2
2017 R. Messerer, C. Dallanoce, C. Matera, S. Wehle, L. Flammini, B. Chirinda, A. Bock, M. Irmen, C. Tränkle, E. Barocelli, M. Decker, C. Sotriffer, M. De Amici, U. Holzgrabe
G protein inhibitors unravel Gq-dependent adenylyl cyclase activation in CHO-M1 cells
2017 T. Bödefeld, C. Matera, C. Dallanoce, R. Messerer, U. Holzgrabe, M. De Amici, K. Mohr, R. Schrage
A new molecular mechanism to engineer protean agonism at a G protein-coupled receptor
2017 A. De Min, C. Matera, A. Bock, J. Holze, J. Kloeckner, M. Muth, C. Traenkle, M. De Amici, T. Kenakin, U. Holzgrabe, C. Dallanoce, E. Kostenis, K. Mohr, R. Schrage
Optical Control Of Muscarinic Acetylcholine Receptors Using Photoswitchable Bitopic Ligands
2017 F. Riefolo, A. Garrido‐charles, C. Matera, E. Claro, R. Masgrau, N. Camarero, A. Gomila‐juanela, P. Gorostiza
Synthesis of a group of novel Xanomeline/77-LH-28-1 hybrid ligands and their FRET investigation at muscarinic acetylcholine receptor subtypes
2017 D. Cirillo, M. Kauk, C. Matera, D. Volpato, U. Holzgrabe, M. De Amici, C. Hoffmann, C. Dallanoce
Optical control of muscarinic acetylcholine receptors using photoswitchable bitopic ligands
2017 F. Riefolo, A. Garrido-Charles, C. Matera, E. Claro, R. Masgrau, N. Camarero, A. Gomila-Juanela, P. Gorostiza
Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2-Isoxazoline Scaffold : Synthesis and Electrophysiological Evaluation
2017 M. Quadri, C. Matera, A. Silnovic, M.C. Pismataro, N.A. Horenstein, C. Stokes, R.L. Papke, C. Dallanoce
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation
2018 M. Quadri, A. Silnovic, C. Matera, N.A. Horenstein, C. Stokes, M. De Amici, R.L. Papke, C. Dallanoce
A photoswitchable antimetabolite for targeted photoactivated chemotherapy
2018 C. Matera, A. Gomila-Juaneda, N. Camarero, M. Libergoli, C. Soler, P. Gorostiza
Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy
2018 C. Matera, A.M.J. Gomila, N. Camarero, M. Libergoli, C. Soler, P. Gorostiza
In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton
2018 C. Matera, G. Dondio, D. Braida, L. Ponzoni, M. De Amici, M. Sala, C. Dallanoce
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells
2018 I. Cristofaro, Z. Spinello, C. Matera, M. Fiore, L. Conti, M. De Amici, C. Dallanoce, A.M. Tata
A Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors
2018 L. Rizzi, C. Gotti, M. De Amici, C. Dallanoce, C. Matera
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance
2018 I. Cristofaro, Z. Spinello, C. Matera, L. Spagnuolo, M. Fiore, L. Conti, M. De Amici, C. Dallanoce, A.M. Tata
A drug to photocontrol endogenous muscarinic acetylcholine receptors in vivo
2018 F. Riefolo, C. Matera, A. Garrido-Charles, A. Gomila, L. Agnetta, E. Claro, R. Masgrau, U. Holzgrabe, M. Batlle, M. Decker, E. Guasch, P. Gorostiza
Control of Cardiac Function in vivo with a Light-Regulated Drug
2019 F. Riefolo, C. Matera, A. Garrido-Charles, A.M.J. Gomila, L. Agnetta, E. Claro, R. Masgrau, U. Holzgrabe, M. Batlle, M. Decker, E. Guasch, P. Gorostiza
A novel GABAA receptor ligand derivative that photoswitches with red light
2019 R. Castagna, C. Matera, H. Lee, G. Maleeva, P. Bregestovski, P. Gorostiza
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