Transplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). (1) evolutionary approach to cancer care that includes liver transplantation; (2) elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; (3) exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; (4) extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities.
Transplant Oncology in Primary and Metastatic Liver Tumors: Principles, Evidence, and Opportunities / G. Sapisochin, T. Hibi, C. Toso, K. Man, M. Berenguer, J. Heimbach, T.F. Greten, T.J. Pugh, L.A. Dawson, V. Mazzaferro. - In: ANNALS OF SURGERY. - ISSN 0003-4932. - 273:3(2021 Mar), pp. 483-493. [10.1097/SLA.0000000000004071]
Transplant Oncology in Primary and Metastatic Liver Tumors: Principles, Evidence, and Opportunities
V. Mazzaferro
2021
Abstract
Transplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). (1) evolutionary approach to cancer care that includes liver transplantation; (2) elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; (3) exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; (4) extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities.File | Dimensione | Formato | |
---|---|---|---|
Transplant Oncology in Primary and Metastatic Liver Tumors_Principles, Evidence, and Opportunities.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
512.4 kB
Formato
Adobe PDF
|
512.4 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.