Sodium glucose cotransporter inhibitors (SGLTi) are oral hypoglycemic drugs that reduce renal glucose re-uptake and induce glycosuria. SGLTi have been successfully tested in large randomized clinical trials for type 2 diabetes, and several molecules have been approved in this setting by the international pharmaceutical agencies. Additionally, recent evidence has shown that SGLTi may be useful also in type 1 diabetes (T1D). Indeed, these drugs can be used as an ancillary to insulin to improve glycemic control and reduce insulin dosage, and such regimens have been associated with a lower rate of hypoglycemic episodes. The pharmacological effects of SGLTi therapy are described herein, and we also discuss the future use of SGLTi in T1D.
Sodium glucose cotransporters inhibitors in type 1 diabetes / S. Dellepiane, M. Ben Nasr, E. Assi, V. Usuelli, T. Letizia, F. D'Addio, G.V. Zuccotti, P. Fiorina. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 133(2018 Apr 22), pp. 1-8.
Sodium glucose cotransporters inhibitors in type 1 diabetes
M. Ben Nasr;E. Assi;V. Usuelli;T. Letizia;F. D'Addio;G.V. Zuccotti;P. Fiorina
Ultimo
2018
Abstract
Sodium glucose cotransporter inhibitors (SGLTi) are oral hypoglycemic drugs that reduce renal glucose re-uptake and induce glycosuria. SGLTi have been successfully tested in large randomized clinical trials for type 2 diabetes, and several molecules have been approved in this setting by the international pharmaceutical agencies. Additionally, recent evidence has shown that SGLTi may be useful also in type 1 diabetes (T1D). Indeed, these drugs can be used as an ancillary to insulin to improve glycemic control and reduce insulin dosage, and such regimens have been associated with a lower rate of hypoglycemic episodes. The pharmacological effects of SGLTi therapy are described herein, and we also discuss the future use of SGLTi in T1D.File | Dimensione | Formato | |
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