The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading “activation memories” between inhibitory synapses. Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling.
Inter-synaptic lateral diffusion of GABAA receptors shapes inhibitory synaptic currents / D.L. E., R. T., P. E. M., P. A., T. Nieus, G. S., B. A.. - In: NEURON. - ISSN 0896-6273. - 95:1(2017 Jul), pp. 63-69.e1-e5. [10.1016/j.neuron.2017.06.022]
Inter-synaptic lateral diffusion of GABAA receptors shapes inhibitory synaptic currents
T. Nieus;
2017
Abstract
The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading “activation memories” between inhibitory synapses. Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling.File | Dimensione | Formato | |
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