Deuterium incorporation in the 5-substituted pyrazoles arising from the copper(I)-catalysed reaction between chlorohydrazones and terminal acetylenes suggest the intermediacy of copper(I)-complexed alkynylhydrazones. Since the efficiency of such a complexation depends on both the chlorohydrazone and the solvent, the obtainment of the pyrazoles and/or the corresponding alkynylhydrazones is variable depending on the reaction conditions. Copper(I)-complexed alkynylhydrazone intermediates should play a pivotal role in the proposed catalytic cycle
Mechanistic insights of the copper(I)-catalysed reaction between chlorohydrazones and terminal alkynes / A. Ponti, A. Silvani, G. Molteni. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - (2023), pp. 1-6. [Epub ahead of print] [10.1039/D3NJ02712K]
Mechanistic insights of the copper(I)-catalysed reaction between chlorohydrazones and terminal alkynes
A. SilvaniPenultimo
Supervision
;G. Molteni
Ultimo
Writing – Review & Editing
2023
Abstract
Deuterium incorporation in the 5-substituted pyrazoles arising from the copper(I)-catalysed reaction between chlorohydrazones and terminal acetylenes suggest the intermediacy of copper(I)-complexed alkynylhydrazones. Since the efficiency of such a complexation depends on both the chlorohydrazone and the solvent, the obtainment of the pyrazoles and/or the corresponding alkynylhydrazones is variable depending on the reaction conditions. Copper(I)-complexed alkynylhydrazone intermediates should play a pivotal role in the proposed catalytic cycleFile | Dimensione | Formato | |
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