This Review summarizes the advances in the catalytic enantioselective mono- and difunctionalization of alkenes, highlighting the fundamental role of ligands. Several types of asymmetric reactions have been developed involving different bonds formation, C-O, C-N and C-C, highlighting the urgency to go ahead in the search for new ligands and synthetic methodologies in order to improve the control over the reaction selectivity and activity and thus, to increase the applications in the synthesis of heterocyclic scaffolds and biologically active compounds. The Review is organized into paragraphs, which discuss the type of bond formed during the nucleopalladation, C-O, C-N, C-C bonds, and the type of reaction involved.
Asymmetric Pd(II)‐Catalyzed C−O, C−N, C−C Bond Formation Using Alkenes as Substrates: Insight into Recent Enantioselective Developments / S. Giofrè, L. Molteni, E.M. Beccalli. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - 26:2(2023 Jan 10), pp. e202200976.1-e202200976.34. [10.1002/ejoc.202200976]
Asymmetric Pd(II)‐Catalyzed C−O, C−N, C−C Bond Formation Using Alkenes as Substrates: Insight into Recent Enantioselective Developments
L. MolteniPenultimo
;E.M. BeccalliUltimo
2023
Abstract
This Review summarizes the advances in the catalytic enantioselective mono- and difunctionalization of alkenes, highlighting the fundamental role of ligands. Several types of asymmetric reactions have been developed involving different bonds formation, C-O, C-N and C-C, highlighting the urgency to go ahead in the search for new ligands and synthetic methodologies in order to improve the control over the reaction selectivity and activity and thus, to increase the applications in the synthesis of heterocyclic scaffolds and biologically active compounds. The Review is organized into paragraphs, which discuss the type of bond formed during the nucleopalladation, C-O, C-N, C-C bonds, and the type of reaction involved.File | Dimensione | Formato | |
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Eur J Org Chem - 2022 - Giofr - Asymmetric Pd II ‐Catalyzed C O C N C C Bond Formation Using Alkenes as Substrates .pdf
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Eur J Org Chem - 2022 - Giofr - Asymmetric Pd II ‐Catalyzed C O C N C C Bond Formation Using Alkenes as Substrates _compressed.pdf
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