Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The distribution of these variants (BRCA1 vs. BRCA2) in Ashkenazi men with prostate cancer is not clear.
Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis / A. Cioffi, O. De Cobelli, P. Veronesi, C. La Vecchia, P. Maisonneuve, G. Corso. - In: CANCERS. - ISSN 2072-6694. - 15:1(2023 Jan 02), pp. 306.1-306.11. [10.3390/cancers15010306]
Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis
O. De CobelliSecondo
;P. Veronesi;C. La Vecchia;G. Corso
Ultimo
2023
Abstract
Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The distribution of these variants (BRCA1 vs. BRCA2) in Ashkenazi men with prostate cancer is not clear.
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Pevalence of Germline_Cioffi_cancers-15-00306.pdf
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