Lipid metabolism impacts immune cell differentiation, activation, and functions, modulating inflammatory mediators, energy homeostasis, and cell membrane composition. Despite preclinical evidence, data in humans lack concerning tumors and immunotherapy (IO). We aimed at investigating the correlations between circulating lipids and the outcome of non-small cell lung cancer (NSCLC) patients treated with IO.
Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer / G. Galli, P.A. Corsetto, C. Proto, G. Lo Russo, M. Ganzinelli, E. Rulli, L. Legramandi, D. Morelli, R. Ferrara, A. Prelaj, D. Signorelli, A. De Toma, M. Brambilla, M. Occhipinti, S. Manglaviti, M. Boeri, A. Martinetti, A. Vingiani, M.P. Colombo, A.M. Rizzo, V. Torri, F. de Braud, S. Sangaletti, A. Sica, M.C. Garassino. - In: CLINICAL LUNG CANCER. - ISSN 1525-7304. - (2022), pp. 1-11. [Epub ahead of print] [10.1016/j.cllc.2022.07.010]
Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer
G. Galli
Co-primo
;P.A. CorsettoCo-primo
;M. Brambilla;M. Occhipinti;S. Manglaviti;A. Vingiani;A.M. Rizzo;F. de Braud;
2022
Abstract
Lipid metabolism impacts immune cell differentiation, activation, and functions, modulating inflammatory mediators, energy homeostasis, and cell membrane composition. Despite preclinical evidence, data in humans lack concerning tumors and immunotherapy (IO). We aimed at investigating the correlations between circulating lipids and the outcome of non-small cell lung cancer (NSCLC) patients treated with IO.
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