The process of growth, which is common to all multicellular organisms, is complex and involves the interaction of a multiplicity of factors; despite this, the GH/IGF function still maintains its preminence, and, in turn, the same is true for all approaches aimed at reducing the consequences of GH/IGF excess. In this review paper, we will deal briefly with some aspects of GH/IGF mechanism of action which are instrumental to the appreciation of a novel class of a "designer" GH antagonist, for use in conditions characterized by excess GH action and elevated serum IGF-I.

Mechanisms of action of GH / E.E. Muller, A.E. Rigamonti, S.G. Cella. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 26:10 Suppl(2003), pp. 2-15.

Mechanisms of action of GH

E.E. Muller
Primo
;
A.E. Rigamonti
Secondo
;
S.G. Cella
Ultimo
2003

Abstract

The process of growth, which is common to all multicellular organisms, is complex and involves the interaction of a multiplicity of factors; despite this, the GH/IGF function still maintains its preminence, and, in turn, the same is true for all approaches aimed at reducing the consequences of GH/IGF excess. In this review paper, we will deal briefly with some aspects of GH/IGF mechanism of action which are instrumental to the appreciation of a novel class of a "designer" GH antagonist, for use in conditions characterized by excess GH action and elevated serum IGF-I.
Settore BIO/14 - Farmacologia
2003
https://www.scopus.com/record/display.uri?eid=2-s2.0-16644376331&origin=inward&txGid=E478BC17FD792F56B98A42605631B544.wsnAw8kcdt7IPYLO0V48gA%3a2
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/8176
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact