In the past two decades, growth hormone (GH) has been considered as a performance-enhancing drug in the sport world, certainly favoured by the awareness that there is not yet an approved method for detecting its abuse. Because resting or random measurements of plasma GH concentrations per se are meaningless, new methods have been devised to evaluate plasma levels of GH-sensitive substances that are more stable, and hence detectable, than the hormone itself. This review discusses some of the most recently proposed approaches, including a diagnostic algorithm, based on the timed application of different tests, which, collectively, would have a high diagnostic capability. (copyright) 2005 Elsevier Ltd. All rights reserved.

Growth hormone abuse : Methods of detection / A. Rigamonti, S. Cella, N. Marazzi, L. Di Luigi, A. Sartorio, E. Müller. - In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. - ISSN 1043-2760. - 16:4(2005), pp. 160-166. [10.1016/j.tem.2005.03.009]

Growth hormone abuse : Methods of detection

A. Rigamonti
Secondo
;
S. Cella
Primo
;
E. Müller
Ultimo
2005

Abstract

In the past two decades, growth hormone (GH) has been considered as a performance-enhancing drug in the sport world, certainly favoured by the awareness that there is not yet an approved method for detecting its abuse. Because resting or random measurements of plasma GH concentrations per se are meaningless, new methods have been devised to evaluate plasma levels of GH-sensitive substances that are more stable, and hence detectable, than the hormone itself. This review discusses some of the most recently proposed approaches, including a diagnostic algorithm, based on the timed application of different tests, which, collectively, would have a high diagnostic capability. (copyright) 2005 Elsevier Ltd. All rights reserved.
amino terminal sequence ; arthralgia ; athlete ; blood analysis ; body fluid ; bone turnover ; drug abuse ; exercise ; glucose intolerance ; glycosylation ; growth hormone blood level ; growth hormone release ; human ; hypophysis ; insulin resistance ; muscle atrophy ; muscle growth ; muscle hypertrophy ; muscle strength ; muscle weakness ; peripheral edema ; priority journal ; review ; screening test ; urinalysis ; biochemical marker ; collagen ; connective tissue growth factor ; ghrelin ; growth hormone releasing factor ; growth hormone ; peptide hormone ; somatomedin C
Settore BIO/14 - Farmacologia
2005
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/8133
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