The present study aims to demonstrate (i) if oral melatonin in the diet improves adverse cardiac mitochondrial changes triggered by an obesogenic high-fat diet in mice and (ii) if reduced SIRT1 availability in heterozygous mice (HET) influences melatonin efficacy under the same dietary regimen. Our data suggest that melatonin improves cardiac mitochondria in anabolic conditions triggered by a high-calorie lard-based diet in mice but only in the presence of full availability of sirtuin 1. Nevertheless, further biochemical and molecular studies are needed to best clarify their strict interdependence, so opening new avenues to melatonin supplementation in clinical trials.
Melatonin fails to protect cardiac mitochondria in sirtuin 1 heterozygous mice placed on a high-fat diet / A. Stacchiotti, R. Garcia-Gomez, A. Lavazza, M. Monsalve, R. Rezzani - In: Proceedings 14th Multinational Congress on Microscopy / [a cura di] J.G.Novakovic, N. Nestorovic, D. Rajnovic. - [s.l] : University of Belgrade, 2019. - ISBN 9788680335117. - pp. 259-260 (( Intervento presentato al 14. convegno Multinational congress on microscopy tenutosi a Belgrade nel 2019.
Melatonin fails to protect cardiac mitochondria in sirtuin 1 heterozygous mice placed on a high-fat diet
A. Stacchiotti;
2019
Abstract
The present study aims to demonstrate (i) if oral melatonin in the diet improves adverse cardiac mitochondrial changes triggered by an obesogenic high-fat diet in mice and (ii) if reduced SIRT1 availability in heterozygous mice (HET) influences melatonin efficacy under the same dietary regimen. Our data suggest that melatonin improves cardiac mitochondria in anabolic conditions triggered by a high-calorie lard-based diet in mice but only in the presence of full availability of sirtuin 1. Nevertheless, further biochemical and molecular studies are needed to best clarify their strict interdependence, so opening new avenues to melatonin supplementation in clinical trials.File | Dimensione | Formato | |
---|---|---|---|
Stacchiotti et alMCM2019pag259-260,2019 (1).pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
330.13 kB
Formato
Adobe PDF
|
330.13 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.