Recent data suggest that IL-1-like molecules have been conserved during evolution. The signal transduction mechanism of IL-1 is not known, but kinase activation has been reported. With the aim of studying if human IL-1 has any effect on the leech nervous system, we have added this cytokine to segmental ganglia labeled with [32P]ortophosphoric acid; proteins have been separated by electrophoresis and phosphoproteins detected by autoradiography. In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin.
Interleukin-1 and interleukin-6 modify protein phosphorylation in the central nervous system of Hirudo medicinalis / D. Bottai, M. Garcia-Gil, M.L. Zaccardi, L. Fineschi, M. Brunelli. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 641:1(1994), pp. 155-159.
Interleukin-1 and interleukin-6 modify protein phosphorylation in the central nervous system of Hirudo medicinalis
D. BottaiPrimo
;
1994
Abstract
Recent data suggest that IL-1-like molecules have been conserved during evolution. The signal transduction mechanism of IL-1 is not known, but kinase activation has been reported. With the aim of studying if human IL-1 has any effect on the leech nervous system, we have added this cytokine to segmental ganglia labeled with [32P]ortophosphoric acid; proteins have been separated by electrophoresis and phosphoproteins detected by autoradiography. In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin.
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