Four peptides corresponding to highly conserved motives within the first two RNA recognition motif-type domains of ELAV proteins were prepared, and their effect on the stability of NOVA-1 and VEGF ELAV-target mRNAs was evaluated. Biological results show that in the presence of phorbol 12-myristate 13-acetate (a PKC activator triggering the ELAV pathway), an equimolar mixture of peptides induces a statistically significant stabilization of the selected transcripts, suggesting a synergic effect of the two stimuli.
Discovery of small peptides derived from ELAV proteins structure showing RNA-stabilizing properties / D. Rossi, M. Amadio, A. Carnevale Baraglia, O. Azzolina, A. Ratti, S. Govoni, A. Pascale, S. Collina. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 52:16(2009 Aug), pp. 5017-5019. [10.1021/jm900741e]
Discovery of small peptides derived from ELAV proteins structure showing RNA-stabilizing properties
A. Ratti;
2009
Abstract
Four peptides corresponding to highly conserved motives within the first two RNA recognition motif-type domains of ELAV proteins were prepared, and their effect on the stability of NOVA-1 and VEGF ELAV-target mRNAs was evaluated. Biological results show that in the presence of phorbol 12-myristate 13-acetate (a PKC activator triggering the ELAV pathway), an equimolar mixture of peptides induces a statistically significant stabilization of the selected transcripts, suggesting a synergic effect of the two stimuli.
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