In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.
Macrophage fusion cuisine / A. Sica, A. Mantovani. - In: BLOOD. - ISSN 0006-4971. - 114:21(2009 Nov 19), pp. 4609-4610.
Macrophage fusion cuisine
A. MantovaniUltimo
2009
Abstract
In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.
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