A randomized clinical trial was designed to evaluate the effect of daily high-dose xylitol chewing gum on plaque pH and salivary mutans streptococci (MS) in a sample of schoolchildren at high risk of caries. The study was performed on 204 subjects (acceptance rate 88.3%). Inclusion criteria were: >1 and <4 carious lesions, and a salivary MS concentration >105 CFU/ml. Subjects were randomly assigned to the xylitol or control group. Study design included one examination at baseline (t0), one after 3 months of chewing (t1), one after 6 months of chewing (t2) and the last 3 months after the end of chewing period (t3). Plaque pH was assessed using the MicroTouch technique, following a sucrose challenge. The area under the curve (AUC5.7 and AUC6.2) was recorded. Whole saliva was collected in sterile vials and MS CFU/ml were counted. Data were analysed using repeated-measures ANOVA. The main result was that plaque acidogenicity was reduced in both groups. The differences between treatments were statistically significant both for plaque pH and MS concentration; the interaction term for treatment and time was statistically significant (p < 0.01). At t2, the xylitol group children with a salivary MS concentration >105 and those with ≤105 showed significantly lower AUC5.7 and AUC6.2 values than the control group. These results suggest that the long-term use of high-dose non-sucrose chewing gums had beneficial effects on plaque pH, and that this effect was statistically greater when using xylitol chewing gums, both on plaque pH and MS salivary concentration. Copyright

Six months of daily high-dose xylitol in high-risk schoolchildren : a randomized clinical trial on plaque pH and salivary mutans streptococci / G. Campus, M.G. Cagetti, G. Sacco, G. Solinas, S. Mastroberardino, P. Lingström. - In: CARIES RESEARCH. - ISSN 0008-6568. - 43:6(2009 Dec 10), pp. 455-461.

Six months of daily high-dose xylitol in high-risk schoolchildren : a randomized clinical trial on plaque pH and salivary mutans streptococci

M.G. Cagetti
Secondo
;
2009

Abstract

A randomized clinical trial was designed to evaluate the effect of daily high-dose xylitol chewing gum on plaque pH and salivary mutans streptococci (MS) in a sample of schoolchildren at high risk of caries. The study was performed on 204 subjects (acceptance rate 88.3%). Inclusion criteria were: >1 and <4 carious lesions, and a salivary MS concentration >105 CFU/ml. Subjects were randomly assigned to the xylitol or control group. Study design included one examination at baseline (t0), one after 3 months of chewing (t1), one after 6 months of chewing (t2) and the last 3 months after the end of chewing period (t3). Plaque pH was assessed using the MicroTouch technique, following a sucrose challenge. The area under the curve (AUC5.7 and AUC6.2) was recorded. Whole saliva was collected in sterile vials and MS CFU/ml were counted. Data were analysed using repeated-measures ANOVA. The main result was that plaque acidogenicity was reduced in both groups. The differences between treatments were statistically significant both for plaque pH and MS concentration; the interaction term for treatment and time was statistically significant (p < 0.01). At t2, the xylitol group children with a salivary MS concentration >105 and those with ≤105 showed significantly lower AUC5.7 and AUC6.2 values than the control group. These results suggest that the long-term use of high-dose non-sucrose chewing gums had beneficial effects on plaque pH, and that this effect was statistically greater when using xylitol chewing gums, both on plaque pH and MS salivary concentration. Copyright
Chewing gum; Mutans streptococci; Plaque pH; Xylitol
Settore MED/28 - Malattie Odontostomatologiche
10-dic-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/69915
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