We have previously demonstrated that Gam1, an avian adenoviral protein inhibits sumoylation. By counteracting the SUMO pathway, Gam1 has a significant impact on virus-infected cells, but in isolation the inhibitory effects of the Gam1 protein can be exploited to intentionally manipulate the SUMO system in vivo or in vitro. Here we discuss in detail the techniques we use to inhibit the SUMO pathway using the Gam1 protein.
Inhibition of the SUMO pathway by Gam1 / M. Pozzebon, C.V. Segré, S. Chiocca - In: SUMO protocols / [a cura di] H.D. Ulrich. - New York : Humana Press, 2009. - ISBN 978-1-934115-80-0. - pp. 285-301 [10.1007/978-1-59745-566-4]
Inhibition of the SUMO pathway by Gam1
M. PozzebonPrimo
;C.V. SegréSecondo
;
2009
Abstract
We have previously demonstrated that Gam1, an avian adenoviral protein inhibits sumoylation. By counteracting the SUMO pathway, Gam1 has a significant impact on virus-infected cells, but in isolation the inhibitory effects of the Gam1 protein can be exploited to intentionally manipulate the SUMO system in vivo or in vitro. Here we discuss in detail the techniques we use to inhibit the SUMO pathway using the Gam1 protein.
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