We evaluated the COBAS Ampliscreen hepatitis B virus (HBV) test using standards, seroconversion panels, consecutive donations, and samples from patients with abnormal alanine aminotransferase and chronic hepatitis C. Specificity was 100% and sensitivity was 20 IU/ml. In seroconversion panels, HBV DNA was detected up to 4 to 18 days before HBsAg, suggesting that this assay is useful in shortening the infectious window phase.
Multicenter evaluation of a semiautomated, standardized assay for detection of hepatitis B virus DNA in blood donations / L. Romanò, C. Velati, L. Baruffi, L. Fomiatti, G. Colucci, A.R. Zanetti. - In: JOURNAL OF CLINICAL MICROBIOLOGY. - ISSN 0095-1137. - 43:6(2005), pp. 2991-2993. [10.1128/JCM.43.6.2991-2993.2005]
Multicenter evaluation of a semiautomated, standardized assay for detection of hepatitis B virus DNA in blood donations
L. RomanòPrimo
;A.R. ZanettiUltimo
2005
Abstract
We evaluated the COBAS Ampliscreen hepatitis B virus (HBV) test using standards, seroconversion panels, consecutive donations, and samples from patients with abnormal alanine aminotransferase and chronic hepatitis C. Specificity was 100% and sensitivity was 20 IU/ml. In seroconversion panels, HBV DNA was detected up to 4 to 18 days before HBsAg, suggesting that this assay is useful in shortening the infectious window phase.
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