We here show that repeated administration of the first generation antipsychotic haloperidol, but not of the second generation olanzapine, significantly reduced the expression of NMDA subunit NR2A at striatal synapses, whereas both drugs decreased alpha CaMKII protein levels and autophosphorylation degree. Given that alterations in the localization of NMDA receptor regulatory subunits at synapses have been described in experimental parkinsonism, the haloperidol-induced effect on NMDA subunit localization might contribute to drug-induced parkinsonism induced by haloperidol
Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum / F. Gardoni, A. Frasca, E. Zianni, M.A. Riva, M. Di Luca, F. Fumagalli. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 18:7(2008 Jul), pp. 531-534.
Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum
F. GardoniPrimo
;A. FrascaSecondo
;E. Zianni;M.A. Riva;M. Di LucaPenultimo
;F. FumagalliUltimo
2008
Abstract
We here show that repeated administration of the first generation antipsychotic haloperidol, but not of the second generation olanzapine, significantly reduced the expression of NMDA subunit NR2A at striatal synapses, whereas both drugs decreased alpha CaMKII protein levels and autophosphorylation degree. Given that alterations in the localization of NMDA receptor regulatory subunits at synapses have been described in experimental parkinsonism, the haloperidol-induced effect on NMDA subunit localization might contribute to drug-induced parkinsonism induced by haloperidolPubblicazioni consigliate
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