Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.
γ-Glutamyltransferase, redox regulation and cancer drug resistance / A. Pompella, A. Corti, A. Paolicchi, C. Giommarelli, F. Zunino. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 7:4(2007 Aug), pp. 360-366.
γ-Glutamyltransferase, redox regulation and cancer drug resistance
C. GiommarelliPenultimo
;
2007
Abstract
Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.
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