The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 μg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 μg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43 ± 1.74 μg/ml) and of the haem detoxification to haemozoin.
Anti-plasmodial activity of Ailanthus excelsa / M. Dell'Agli, G. Galli, S. Parapini, N. Basilico, D. Taramelli, A. Said, K. Rashed, E.A. Bosisio. - In: FITOTERAPIA. - ISSN 1971-551X. - 79:2(2008), pp. 112-116.
Anti-plasmodial activity of Ailanthus excelsa
M. Dell'AgliPrimo
;G. GalliSecondo
;S. Parapini;N. Basilico;D. Taramelli;E.A. BosisioUltimo
2008
Abstract
The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 μg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 μg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43 ± 1.74 μg/ml) and of the haem detoxification to haemozoin.
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