Adducin regulates tubular absorption of sodium by modulating the expression levels of the sodium-potassium-ATPase in renal tubular cells. Adducin is a candidate gene in the pathogenesis of hypertension. Yeast two hybrid screen showed a specific interaction between human alpha Adducin and the regulatory factor for X box (RFX-1), a nuclear protein that down regulates the expression of several proteins in non neuronal cells. The interaction was confirmed in cells through co-immunoprecipitation and colocalization experiments. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I.
RFX-1, a putative alpha Adducin interacting protein in a human kidney library / R. Boito, M. Menniti, R. Amato, C. Palmieri, C. Marinaro, R. Iuliano, G. Tripodi, D. Cusi, G. Fuiano, N. Perrotti. - In: FEBS LETTERS. - ISSN 0014-5793. - 579:28(2005 Nov 21), pp. 6439-6443. [10.1016/j.febslet.2005.10.040]
RFX-1, a putative alpha Adducin interacting protein in a human kidney library
D. Cusi;
2005
Abstract
Adducin regulates tubular absorption of sodium by modulating the expression levels of the sodium-potassium-ATPase in renal tubular cells. Adducin is a candidate gene in the pathogenesis of hypertension. Yeast two hybrid screen showed a specific interaction between human alpha Adducin and the regulatory factor for X box (RFX-1), a nuclear protein that down regulates the expression of several proteins in non neuronal cells. The interaction was confirmed in cells through co-immunoprecipitation and colocalization experiments. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I.File | Dimensione | Formato | |
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