The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker–Venkataraman chain elongation and an acid-catalyzed cyclization for the construction of the pyrone ring.
First Total Synthesis of Topopyrone C / S. Gattinoni, S. Dallavalle, L. Merlini. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 48:6(2007 Feb 05), pp. 1049-1051. [10.1016/j.tetlet.2006.11.164]
First Total Synthesis of Topopyrone C
S. GattinoniPrimo
;S. DallavalleSecondo
;L. MerliniUltimo
2007
Abstract
The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker–Venkataraman chain elongation and an acid-catalyzed cyclization for the construction of the pyrone ring.
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