Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies have linked PM exposures with blood DNA hypomethylation, an epigenetic alteration that activates inflammatory and vascular responses. No experimental evidence is available to confirm those observational data and demonstrate the relations between PM, hypomethylation, and BP.
DNA hypomethylation, ambient particulate matter, and increased blood pressure : findings from controlled human exposure experiments / A. Bellavia, B. Urch, M. Speck, R.D. Brook, J.A. Scott, B. Albetti, B. Behbod, M. North, L. Valeri, P.A. Bertazzi, F. Silverman, D. Gold, A. Baccarelli. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 2:3(2013 Jun), pp. e000212.1-e000212.10.
DNA hypomethylation, ambient particulate matter, and increased blood pressure : findings from controlled human exposure experiments
P.A. Bertazzi;A. BaccarelliUltimo
2013
Abstract
Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies have linked PM exposures with blood DNA hypomethylation, an epigenetic alteration that activates inflammatory and vascular responses. No experimental evidence is available to confirm those observational data and demonstrate the relations between PM, hypomethylation, and BP.Pubblicazioni consigliate
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