The intramol. Pd(II)-mediated cyclization of 1-allyl-2-indolecarboxamides leads to pyrazino[1,2-a]indoles through the conversion of the olefinic C-H bond into a C-N bond by reaction with an amide group. When operating on the allylamide, a domino process was obsd. with a double C-H functionalization. [on SciFinder (R)]

Pd-catalyzed cyclization of 1-allyl-2-indolecarboxamides by intramolecular amidation of unactivated ethylenic bond / G. Abbiati, E.M. Beccalli, G. Broggini, M. Martinelli, G. Paladino. - In: SYNLETT. - ISSN 0936-5214. - 2006:1(2006), pp. D30505ST.73-D30505ST.76.

Pd-catalyzed cyclization of 1-allyl-2-indolecarboxamides by intramolecular amidation of unactivated ethylenic bond

G. Abbiati
Primo
;
E.M. Beccalli
Secondo
;
M. Martinelli
Penultimo
;
G. Paladino
Ultimo
2006

Abstract

The intramol. Pd(II)-mediated cyclization of 1-allyl-2-indolecarboxamides leads to pyrazino[1,2-a]indoles through the conversion of the olefinic C-H bond into a C-N bond by reaction with an amide group. When operating on the allylamide, a domino process was obsd. with a double C-H functionalization. [on SciFinder (R)]
amidation ; cyclization ; fused-ring systems ; indoles ; palladium ; unactivated alkenes
Settore CHIM/06 - Chimica Organica
2006
http://www.thieme-connect.de/DOI/DOI?10.1055/s-2005-922788
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/22980
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