Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
Decoys and Regulatory Receptors of the IL-1/Toll-Like Receptor Superfamily / C. Garlanda, F. Riva, E. Bonavita, S. Gentile, A. Mantovani. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 4:(2013 Jul 09), pp. 180.1-180.13. [10.3389/fimmu.2013.00180]
Decoys and Regulatory Receptors of the IL-1/Toll-Like Receptor Superfamily
F. RivaSecondo
;S. GentilePenultimo
;A. MantovaniUltimo
2013
Abstract
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.