Università degli Studi di Milano   Archivio Istituzionale della Ricerca
Please use this identifier to cite or link to this item: http://hdl.handle.net/2434/207079

Title: Persistent right aortic arch and associated axial skeletal malformations in cats
Authors: PARMA, PIETRO (Second to last author)
LONGERI, MARIA LINA (Second author)
POLLI, MICHELE
ACOCELLA, FABIO (Last author)
TREMOLADA, GIOVANNI (First author)
Abstract: Persistent right aortic arch (PRAA) in cats is an uncommon vascular anomaly with clinical signs referable to oesophageal obstruction. To our knowledge no reports of axial skeletal malformations concomitant to PRAA have been reported in cats. The aim of this study is to depict a new clinical feature in cats affected by PRAA. In the study six cats with a diagnosis of vascular ring anomaly were enrolled. A complete physical examination, a neurological examination and a total body radiograph were performed on each animal. Four of the six cats showed contemporary PRAA and skeletal malformations. Additionally, for the first time, a genetic test was performed on one subject to detect DNA alterations in the homologous DiGeorge region of cat. The percentage of skeletal malformations reported in the normal population was compared with animals with PRAA and showed a higher frequency. Genetic testing failed to demonstrate a correlation between PRAA and DiGeorge genomic deletion. A review of veterinary and human diseases that presented both conditions was assessed. The few animals enrolled do not allow definitive conclusions. Further studies are required to corroborate the correlation between PRAA and axial skeletal malformations in cats.
Keywords: SURGICAL-CORRECTION ; DIAPHRAGMATIC-HERNIA ; DIGEORGE-SYNDROME ; HEART-DEFECTS ; ANOMALIES ; DOG ; ABNORMALITIES ; 22Q11 ; FAMILY ; KITTEN
MIUR subjects: AGR/17 - Zootecnica Generale e Miglioramento Genetico
VET/09 - Clinica Chirurgica Veterinaria
Publication date: Feb-2013
Digital Object Identifier (DOI): 10.1177/1098612X12459736
Citation: Persistent right aortic arch and associated axial skeletal malformations in cats / G. Tremolada, M. Longeri, M. Polli, P. Parma, F. Acocella. - In: Journal of feline medicine and surgery. - ISSN 1098-612X. - ISSN 1532-2750. - 15:2(2013 Feb), pp. 68-73.
Type: Article (author)

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