high-altitude adaptation leads to progressive increase in arterial Pa(O2). In addition to increased ventilation, better arterial oxygenation may reflect improvements in lung gas exchange. Previous investigations reveal alterations at the alveolar-capillary barrier indicative of decreased resistance to gas exchange with prolonged hypoxia adaptation, but how quickly this occurs is unknown. Carbon monoxide lung diffusing capacity and its major determinants, hemoglobin, alveolar volume, pulmonary capillary blood volume, and alveolar-capillary membrane diffusion, have never been examined with early high-altitude adaptation
High-altitude exposure of three weeks duration increases lung diffusing capacity in humans / P. Agostoni, E.R. Swenson, M. Bussotti, M. Revera, P. Meriggi, A. Faini, C. Lombardi, G. Bilo, A. Giuliano, D. Bonacina, P.A. Modesti, G. Mancia, G. Parati, HIGHCARE Investigators. - In: JOURNAL OF APPLIED PHYSIOLOGY. - ISSN 8750-7587. - 110:6(2011 Jun), pp. 1564-1571.
High-altitude exposure of three weeks duration increases lung diffusing capacity in humans
P. AgostoniPrimo
;
2011
Abstract
high-altitude adaptation leads to progressive increase in arterial Pa(O2). In addition to increased ventilation, better arterial oxygenation may reflect improvements in lung gas exchange. Previous investigations reveal alterations at the alveolar-capillary barrier indicative of decreased resistance to gas exchange with prolonged hypoxia adaptation, but how quickly this occurs is unknown. Carbon monoxide lung diffusing capacity and its major determinants, hemoglobin, alveolar volume, pulmonary capillary blood volume, and alveolar-capillary membrane diffusion, have never been examined with early high-altitude adaptation
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