Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of β-endorphin in mononuclear leukocytes of 30.2 ± 6.9 pg/ 10 6 cells on admission were in the normal range of 20-40 pg/10 6 cells and decreased significantly to 6.9 ± 1.9 pg/10 6 cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated β-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction / T. BURATTI, P. SHRATZENBERGER, S. DUNZENDORFER, S.E. MANFREDA, C. PECHLANER, M. JOANNIDIS, P. SACERDOTE, A.E. PANERAI, C.J. WIEDERMANN. - In: CARDIOLOGY. - ISSN 0008-6312. - 90:1(1998), pp. 43-47.
Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction
P. SACERDOTE;A.E. PANERAIPenultimo
;
1998
Abstract
Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of β-endorphin in mononuclear leukocytes of 30.2 ± 6.9 pg/ 10 6 cells on admission were in the normal range of 20-40 pg/10 6 cells and decreased significantly to 6.9 ± 1.9 pg/10 6 cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated β-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
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