Objective: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. Methods: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). Results: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. Conclusions: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect. Copyright (C) 2010 S. Karger AG, Basel
Pilot Study on Schizophrenia in Sardinia / J. Ott, F. Macciardi, Y. Shen, M.G. Carta, A. Murru, R. Triunfo, R. Robledo, A. Rinaldi, L. Contu, M. Siniscalco. - In: HUMAN HEREDITY. - ISSN 0001-5652. - 70:2(2010), pp. 92-96. [10.1159/000313844]
Pilot Study on Schizophrenia in Sardinia
F. MacciardiSecondo
;
2010
Abstract
Objective: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. Methods: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). Results: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. Conclusions: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect. Copyright (C) 2010 S. Karger AG, BaselPubblicazioni consigliate
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