D2 dopamine receptor activation induces inhibition of adenylate cyclase, with a rapid decrease of cAMP levels, and an ensuing blockade of IP3-dependent release of Ca2+ from intracellular stores. K+ channels are concomitantly activated and Ca2+ channels are possibly also inhibited. The increased K+ conductance causes hyperpolarization, which may be responsible for the abolition of Ca2+ action potentials and [Ca2+], fluctuations occurring both at rest and after activation of receptors coupled to PIP2 hydrolysis. Lucia Vallar and Jacopo Meldolesi analyse this spectrum of intracellular signals which might be sufficient to sustain inhibition of secretion in pituitary lactotroph cells and possibly the other effects of D2 receptors in other cell systems.

Mechanisms of signal transduction at the dopaminergic D2 receptor [Recensione] / L. Vallar, J. Meldolesi. - In: TRENDS IN PHARMACOLOGICAL SCIENCES. - ISSN 0165-6147. - 10:2(1989), pp. 74-77. [10.1016/0165-6147(89)90082-5]

Mechanisms of signal transduction at the dopaminergic D2 receptor

L. Vallar
Primo
;
1989

Abstract

D2 dopamine receptor activation induces inhibition of adenylate cyclase, with a rapid decrease of cAMP levels, and an ensuing blockade of IP3-dependent release of Ca2+ from intracellular stores. K+ channels are concomitantly activated and Ca2+ channels are possibly also inhibited. The increased K+ conductance causes hyperpolarization, which may be responsible for the abolition of Ca2+ action potentials and [Ca2+], fluctuations occurring both at rest and after activation of receptors coupled to PIP2 hydrolysis. Lucia Vallar and Jacopo Meldolesi analyse this spectrum of intracellular signals which might be sufficient to sustain inhibition of secretion in pituitary lactotroph cells and possibly the other effects of D2 receptors in other cell systems.
Dopamine receptors; D2 receptors; signal transduction
Settore BIO/14 - Farmacologia
1989
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/201939
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