96 monotherapies with carbamazepine, phenytoin, phenobarbital and primidone were assessed in 42 patients with partial epilepsy. Those whose seizure frequency was reduced by 75% or more were considered to have improved. In 54 comparisons of monotherapies significant improvement in seizure frequency was achieved in only 16.7% of cases. Nonresponding patients showed practically no change across all comparisons according to the Fischer test.
Carbamazepine, phenytoin and phenobarbital in drug-resistant partial epilepsies / C.M. Cornaggia, M.P. Canevini, D. Giuccioli, C. Pruneri, R. Canger. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - 7:1(1986 Feb), pp. 113-117. [10.1007/BF02230428]
Carbamazepine, phenytoin and phenobarbital in drug-resistant partial epilepsies
M.P. CaneviniSecondo
;
1986
Abstract
96 monotherapies with carbamazepine, phenytoin, phenobarbital and primidone were assessed in 42 patients with partial epilepsy. Those whose seizure frequency was reduced by 75% or more were considered to have improved. In 54 comparisons of monotherapies significant improvement in seizure frequency was achieved in only 16.7% of cases. Nonresponding patients showed practically no change across all comparisons according to the Fischer test.
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