The production of interleukin-2 by in vitro T helper cells in response to synthetic peptides from the envelope of HIV-1 ("peptide response") has been shown in both HIV-exposed HIV-seronegative (HIV-) and HIV-seropositive (HIV+) homosexual men. In this exploratory study, we examine the association of peptide response with sexual risk behavior and indicators of HIV disease progression in 21 HIV- and 17 HIV+ homosexual men examined in the third and fourth years of a natural history project of HIV disease in New York City. Preproject risk behaviors were associated with HIV status only. During-project risk behaviors were associated with peptide response only. There were no significant HIV Status x Peptide Response interactions. In HIV+ men, one of several disease-progression indicators also contributed. Thus, in our sample peptide response appears to reflect relatively recent exposure to HIV-1 by way of sexual risk behavior in both HIV-exposed HIV- and HIV+ men, and, in HIV+ men additionally, immunologieal impairment by disease progression.

Sexual Risk Behavior May Be Associated with T-Helper-Cell Response to HIV-1 Peptides in HIV− and HIV+ Men / H.F.L. Meyer Bahlburg, C. Dolezal, M. Clerici, S. Lederman. - In: AIDS AND BEHAVIOR. - ISSN 1090-7165. - 1:3(1997), pp. 181-190.

Sexual Risk Behavior May Be Associated with T-Helper-Cell Response to HIV-1 Peptides in HIV− and HIV+ Men

M. Clerici
Penultimo
;
1997

Abstract

The production of interleukin-2 by in vitro T helper cells in response to synthetic peptides from the envelope of HIV-1 ("peptide response") has been shown in both HIV-exposed HIV-seronegative (HIV-) and HIV-seropositive (HIV+) homosexual men. In this exploratory study, we examine the association of peptide response with sexual risk behavior and indicators of HIV disease progression in 21 HIV- and 17 HIV+ homosexual men examined in the third and fourth years of a natural history project of HIV disease in New York City. Preproject risk behaviors were associated with HIV status only. During-project risk behaviors were associated with peptide response only. There were no significant HIV Status x Peptide Response interactions. In HIV+ men, one of several disease-progression indicators also contributed. Thus, in our sample peptide response appears to reflect relatively recent exposure to HIV-1 by way of sexual risk behavior in both HIV-exposed HIV- and HIV+ men, and, in HIV+ men additionally, immunologieal impairment by disease progression.
Hiv-disease progression; Homosexual men; Interleukin-2; Sexual risk behavior; T helper cells
Settore MED/04 - Patologia Generale
1997
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/200791
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