The biological features of malignant gliomas include high cell proliferation, extensive local infiltration of tumor cells into normal brain, and marked neovascularization. alphavbeta3 integrin is highly expressed in malignant gliomas and plays a role in glioma growth. This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas.
IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo / L. Bello, V. Lucini, C. Giussani, G. Carrabba, M. Pluderi, F. Scaglione, G. Tomei, R. Villani, P.M. Black, A. Bikfalvi, R.S. Carroll. - In: NEUROSURGERY. - ISSN 0148-396X. - 52:1(2003 Jan), pp. 177-185.
IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo
L. Bello;V. Lucini;F. Scaglione;
2003
Abstract
The biological features of malignant gliomas include high cell proliferation, extensive local infiltration of tumor cells into normal brain, and marked neovascularization. alphavbeta3 integrin is highly expressed in malignant gliomas and plays a role in glioma growth. This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas.
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