Responsabilie di unità operativa nel progetto “Determinanti genici dell'invecchiamento cardiovascolare e diabete”; Ministero della Salute, Progetto di ricerca ex art. 56

Aim of the project is to define the role of p66shc in the regulation of oxidative stress as involved in the pathogenesis of cardiovascular disease. To this aim an integrated molecular approach will be used with intermediate goal: a) determine the role of p66 shc and eps8 gene in eziopathogenesis of metabolic syndrome and associated cardiovascular disease and the molecular mechanism through which these genes control the development of adipose tissue; b) study of the role of p66shc and oxidative stress in ischemia-induced tissue injury and neoangiogenesis in diabetic patients, focusing on the role of EPC in this conditions; c) determine the role of p66 shc and eps8 in TF regulation at the level of heart, lung, and vascular tissue; d) Determine the effect of aging and of p66shc on the capacity of endothelial cells to respond to growth factor such as VEGF and TGF